Article
FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy.
Scientific reports - 6 Sept 2017
Bolte Craig, Flood Hannah M, Ren Xiaomeng, Jagannathan Sajjeev, Barski Artem, Kalin Tanya V, Kalinichenko Vladimir V
Abstract excerpt
FOXF1, a member of the forkhead box family of transcription factors, has been previously shown to be critical for lung development, homeostasis, and injury responses. However, the role of FOXF1 in lung regeneration is unknown. Herein, we performed partial pneumonectomy, a model of lung regeneration, in mice lacking one Foxf1 allele in endothelial cells (PDGFb-iCre/Foxf1 fl/+ mice). Endothelial cell proliferation...
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