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Article

RCC2 is a novel p53 target in suppressing metastasis

4 Sept 2017

Abstract excerpt

RCC2 (also known as TD60) is a highly conserved protein involved in prognosis in colorectal cancer. However, its relationship with tumor development is less understood. Here we demonstrate a signaling pathway defining regulation of RCC2 and its functions in tumor progression. We report that p53 is a transcriptional regulator of RCC2 that acts through its binding to a palindromic motif in the RCC2 promoter. RCC2...

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PMID: 28869598
DOI: 10.1038/onc.2017.306

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