Article
High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing.
The Journal of molecular diagnostics : JMD - 1 Nov 2017
Guan Yinghui, Mayba Oleg, Sandmann Thomas, Lu Shan, Choi Younjeong, Darbonne Walter C, Leveque Vincent, Ryner Lisa, Humke Eric, Tam Nga W R, Sujathasarma Sundari, Cheung Anna, Bourgon Richard, Lackner Mark R, Wang Yulei
Abstract excerpt
Circulating tumor DNA (ctDNA) has potential to serve as a biomarker for noninvasive monitoring of treatment response and disease progression. However, broad clinical applicability of ctDNA has been limited by the low sensitivity, throughput, and patient coverage offered by existing ctDNA detection methods. Herein, we report the adaptation and characterization of the microfluidics multiplex PCR sequencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.