Article
Evaluation of Microscopic Changes in Fallopian Tubes of BRCA Mutation Carriers by Morphometric Analysis of Histologic Slides: A Preliminary Pilot Study.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Sept 2018
Amit Amnon, Sabo Edmond, Zohar Yaniv, Trugman Einat, Pranovich Irena, Reiss Ari, Matanes Emad, Klorin Geula
Abstract excerpt
Mutations in BRCA genes increase the risk of ovarian cancer, yet no method for early diagnosis is available. Some serous ovarian tumors are hypothesized to stem from cells of the fallopian tube fimbria. Using a novel method of computerized morphometry of the fimbrial epithelium, this study aimed to detect morphologic differences in noncancerous fimbriae between BRCA mutation carriers and noncarriers, and between...
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