Article
Association of killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands with susceptibility to Behçet's disease.
Scandinavian journal of rheumatology - 1 Mar 2018
Mohammad-Ebrahim H, Kamali-Sarvestani E, Mahmoudi M, Beigy M, Karami J, Ahmadzadeh N, Shahram F
Abstract excerpt
OBJECTIVES: Behçet's disease (BD) is a systemic inflammatory disorder with remissions and exacerbations. It is thought that defects in the natural killer (NK) cell repertoire may be involved in BD through killer cell immunoglobulin-like receptors (KIRs). This study aimed to evaluate KIR and HLA genes, their interactions in BD patients, and their associations with clinical manifestations. METHOD: The presence or...
Topics
- Adult
- Behcet Syndrome
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA Antigens
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Receptors, KIR