Article
Evaluation of KIR3DL1/KIR3DS1 polymorphism in Behçet's disease.
Genes and immunity - 1 Dec 2016
Erer B, Takeuchi M, Ustek D, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Duymaz-Tozkir J, Gül A, Kastner D L, Remmers E F, Ombrello M J
Abstract excerpt
The Behçet's disease (BD)-associated human leukocyte antigen (HLA) allele, HLA-B*51 (B*51), encodes a ligand for a pair of allelic killer immunoglobulin-like receptors (KIR) present on cytotoxic cells-KIR3DL1, which inhibits their cytotoxicity, and KIR3DS1, which activates their cytotoxic activity. We tested whether KIR-regulated mechanisms contribute to BD by testing for association of KIR3DL1/KIR3DS1 genotypes...
Topics
- Behcet Syndrome
- Genotype
- HLA Antigens
- Humans
- Polymorphism, Single Nucleotide
- Receptors, KIR3DL1
- Receptors, KIR3DS1