Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rank orders of mammalian pathogenicity-related PB2 mutations of avian influenza A viruses.

Scientific reports - 24 Mar 2020

Lee Chung-Young, An Se-Hee, Choi Jun-Gu, Lee Youn-Jeong, Kim Jae-Hong, Kwon Hyuk-Joon

Abstract excerpt

The PB2 gene is one of the key determinants for the mammalian adaptation of avian influenza A viruses (IAVs). Although mammalian pathogenicity-related mutations (MPMs) in PB2 genes were identified in different genetic backgrounds of avian IAVs, the relative effects of single or multiple mutations on viral fitness could not be directly compared. Furthermore, their mutational steps during mammalian adaptation had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birds
Share to Dogs
Share to Influenza A virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza, Human

Share to Influenza in Birds

Share to Mammals

Share to Orthomyxoviridae Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 32210274
DOI: 10.1038/s41598-020-62036-5
PMCID: PMC7093554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rank orders of mammalian pathogenicity-related PB2 mutations of avian influenza A viruses.PMID 32210274Read ↗

Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Semantic proximity Read ↗

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.Semantic proximity Read ↗

The PB2 co‐adaptation of H10N8 avian influenza virus increases the pathogenicity to chickens and miceSemantic proximity Read ↗

Evolution and Virulence of Influenza A Virus Protein PB1-F2Semantic proximity Read ↗

An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hostsSemantic proximity Read ↗

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesSemantic proximity Read ↗

Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in miceSemantic proximity Read ↗

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and PathogenicitySemantic proximity Read ↗

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.Semantic proximity Read ↗

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammalsSemantic proximity Read ↗

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsSemantic proximity Read ↗

Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.