Article
Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection.
Cell reports - 27 Jul 2021
Kwiecinski Jakub M, Kratofil Rachel M, Parlet Corey P, Surewaard Bas G J, Kubes Paul, Horswill Alexander R
Abstract excerpt
Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S. aureus immune evasion in skin is controlled by a cascade composed of the ArlRS two-component regulatory system and its downstream effector, MgrA. S. aureus lacking either ArlRS or MgrA is less virulent and unable...
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