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The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing

30 Aug 2017

Abstract excerpt

ABSTRACT Scarring and fibrotic disease result from the persistence of myofibroblasts characterized by high surface expression of αv integrins and subsequent activation of the transforming growth factor β (TGFβ) proteins; however, the mechanism controlling their surface abundance is unknown. Genetic screening revealed that human primary stromal corneal myofibroblasts overexpress a subset of deubiquitylating...

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PMID: 28851806
DOI: 10.1242/jcs.204628

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