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Article

Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.

JAMA psychiatry - 1 Jul 2014

Nicodemus Kristin K, Hargreaves April, Morris Derek, Anney Richard, Gill Michael, Corvin Aiden, Donohoe Gary

Abstract excerpt

IMPORTANCE: We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), polygenic scores, and epistatic analyses. Of particular importance was the relative contribution of the polygenic score vs epistasis in variation explained. OBJECTIVES: To (1) assess the...

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Identifiers

PMID: 24828433
DOI: 10.1001/jamapsychiatry.2014.528
PMCID: PMC4337973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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