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Novel DNA methylation biomarkers in stool and blood for early detection of colorectal cancer and precancerous lesions

17 Feb 2023

Abstract excerpt

BACKGROUND: Early detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC). Here, we developed new candidate CpG site biomarkers for CRC and evaluated the diagnostic value of their expression in blood and stool samples of CRC and precancerous lesions. METHODS: We analyzed 76 pairs of CRC and adjacent normal tissue samples, 348 stool samples,...

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Share to Colorectal Cancer Screening and Detection
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 36803423
DOI: 10.1186/s13148-023-01443-7

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