Article
The HRH4 rs11662595 mutation is associated with histamine H4 receptor dysfunction and with increased epithelial-to-mesenchymal transition progress in non-small cell lung cancer.
Biochimica et biophysica acta. Molecular basis of disease - 1 Nov 2017
Cai Wen-Ke, Zhang Jia-Bin, Chen Ji-Hui, Meng Jing-Ru, Ma Xue, Zhang Juan, Zhou Ya-Lin, Xu Gui-Li, He Gong-Hao
Abstract excerpt
We previously demonstrated that histamine H4 receptor (HRH4) played important roles to suppress epithelial-to-mesenchymal transition (EMT) progress in non-small cell lung cancer (NSCLC). Furthermore, recent investigations suggested that genetic variations in HRH4 gene affected HRH4 function and eventually contributed to certain HRH4-related diseases. However, the relations between polymorphisms in HRH4 gene and...
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