Article
A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease.
Acta medica Iranica - 1 Jun 2017
Bahrehmand Fariborz, Kiani Amir, Vaisi-Raygani Asad, Bashiri Homayoun, Zobeiri Mehdi, Moini Ali, Pourmotabbed Tayebeh
Abstract excerpt
Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied. This is for the first time that TPMT activity is measured in Iranian IBD patients. We used an improved direct liquid chromatography assay without need for solvent extraction and...
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