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Article

Association between the MTHFR-C677T isoform and structure of sperm DNA.

Journal of assisted reproduction and genetics - 1 Oct 2017

Cornet Dominique, Cohen Marc, Clement Arthur, Amar Edouard, Fournols Laetitia, Clement Patrice, Neveux Paul, Ménézo Yves

Abstract excerpt

PURPOSE: The aim of this study is to evaluate whether the MTHFR contribution to male decreased fertility can be attributable to anomalies in sperm nucleus DNA structure in relation to defective methylation. METHODS: The presence of MTHFR C677T, contributing at most for male infertility, was determined from a venous blood sample, using real-time polymerase chain reaction (PCR). Sperm DNA fragmentation (SDF) and...

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Source

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Identifiers

PMID: 28842818
DOI: 10.1007/s10815-017-1015-2
PMCID: PMC5633564

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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