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Article

Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1.

American journal of physiology. Renal physiology - 1 Dec 2017

Bartlett Christina S, Scott Rizaldy P, Carota Isabel Anna, Wnuk Monika L, Kanwar Yashpal S, Miner Jeffrey H, Quaggin Susan E

Abstract excerpt

Proteinuria has been reported in cancer patients receiving agents that target the transmembrane receptor neuropilin-1 (Nrp1) suggesting potential adverse effects on glomerular function. Here we show that Nrp1 is highly expressed by mesangial cells and that genetic deletion of the Nrp1 gene from PDGF receptor-β+ mesangial cells results in proteinuric disease and glomerulosclerosis, leading to renal failure and...

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Source

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Identifiers

PMID: 28835419
DOI: 10.1152/ajprenal.00311.2017
PMCID: PMC5814644

Genes

PDGFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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