Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous targeted inhibition of Sox2‐Oct4 transcription factors using decoy oligodeoxynucleotides to repress stemness properties in mouse embryonic stem cells

18 Aug 2017

Abstract excerpt

Abstract Transcriptional master regulators like Sox2 and Oct4, which are expressed in various human tumors, have been shown to cause tumor growth promotion as well as epithelial dysplasia by means of interfering with progenitor cell differentiation. In order to investigate the potential of Sox2‐Oct4 transcription factor decoy (TFD) strategy for differentiation therapy, mouse embryonic stem cells (mESCs) were used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Pluripotent Stem Cells Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28833847
DOI: 10.1002/cbin.10847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous targeted inhibition of Sox2‐Oct4 transcription factors using decoy oligodeoxynucleotides to repress stemness properties in mouse embryonic stem cellsPMID 28833847Read ↗

Pluripotency transcription factors and cancer stem cells: small genes make a big differenceSemantic proximity Read ↗

Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilitiesSemantic proximity Read ↗

Transcriptional regulation of nanog by OCT4 and SOX2.Semantic proximity Read ↗

Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.Semantic proximity Read ↗

STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genesSemantic proximity Read ↗

Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells.Semantic proximity Read ↗

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.Semantic proximity Read ↗

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer.Semantic proximity Read ↗

A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells.Semantic proximity Read ↗

Sox2 acts as a transcriptional repressor in neural stem cells.Semantic proximity Read ↗

Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequenceSemantic proximity Read ↗

[Inhibition on phenotypic transformation of detrusor smooth muscle cells after bladder outlet obstruction by E2F decoy strategy].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.