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Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma

5 Jan 2022

Abstract excerpt

Background p53 mutations are highly frequent in various human cancers and are reported to contribute to tumor malignance and chemoresistance. In this study, we explored the mechanism by which mutant p53 promotes carcinogenesis and chemoresistance and provided novel insights into cancer therapy. Materials and methods A total of 409 patients with colorectal carcinoma from TCGA database were subdivided into two...

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PMID: 35071232
DOI: 10.3389/fcell.2021.788331

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