Microenvironmental Interaction Between Hypoxia and Endothelial Cells Controls the Migration Ability of Placenta‐Derived Mesenchymal Stem Cells via α4 Integrin and Rho Signaling

Abstract excerpt

Mesenchymal stem cells (MSCs) are a powerful source for cell therapy in degenerative diseases. The migration ability of MSCs is an important factor that enhances the therapeutic effect of the cells when they are transplanted into target tissues or organs. Hypoxia and the endothelial barrier, which are representative migration microenvironmental factors, are known to be regulated by the integrin-mediated pathway...

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