Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitation of fibroblast activation protein (FAP)‐specific protease activity in mouse, baboon and human fluids and organs

8 Dec 2013

Abstract excerpt

The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline bond was exploited to generate a new specific substrate to quantify FAP enzyme activity. This sensitive assay detected no FAP activity in any tissue or fluid of FAP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuropeptides and Animal Physiology
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24371721
DOI: 10.1016/j.fob.2013.12.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitation of fibroblast activation protein (FAP)‐specific protease activity in mouse, baboon and human fluids and organsPMID 24371721Read ↗

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapySemantic proximity Read ↗

Fibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?Semantic proximity Read ↗

Fibroblast activation protein is dispensable in the anti-influenza immune response in mice.Semantic proximity Read ↗

Targeting Inhibition of Fibroblast Activation Protein-α and Prolyl Oligopeptidase Activities on Cells Common to Metastatic Tumor MicroenvironmentsSemantic proximity Read ↗

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese miceSemantic proximity Read ↗

Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells?Semantic proximity Read ↗

Protease inhibitors: A panacea?Semantic proximity Read ↗

Fibroblast activation protein‐α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterationsSemantic proximity Read ↗

Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.Semantic proximity Read ↗

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived ProbesSemantic proximity Read ↗

Regulation of Fibroblast Activation Protein-α Expression: Focus on Intracellular Protein InteractionsSemantic proximity Read ↗

Multiscale profiling of enzyme activity in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.