Article
Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors.
Vascular medicine (London, England) - 1 Oct 2017
Sangwung Panjamaporn, Zhou Guangjin, Lu Yuan, Liao Xudong, Wang Benlian, Mutchler Stephanie M, Miller Megan, Chance Mark R, Straub Adam C, Jain Mukesh K
Abstract excerpt
Hemoglobin subunit alpha (HBA) expression in endothelial cells (ECs) has recently been shown to control vascular tone and function. We sought to elucidate the transcriptional regulation of HBA expression in the EC. Gain of KLF2 or KLF4 function studies led to significant induction of HBA in ECs. An opposite effect was observed in ECs isolated from animals with endothelial-specific ablation of Klf2, Klf4 or both....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.