Article
Evaluation of the electron transfer flavoprotein as an antibacterial target in Burkholderia cenocepacia.
Canadian journal of microbiology - 1 Oct 2017
Stietz Maria S, Lopez Christina, Osifo Osasumwen, Tolmasky Marcelo E, Cardona Silvia T
Abstract excerpt
There are hundreds of essential genes in multidrug-resistant bacterial genomes, but only a few of their products are exploited as antibacterial targets. An example is the electron transfer flavoprotein (ETF), which is required for growth and viability in Burkholderia cenocepacia. Here, we evaluated ETF as an antibiotic target for Burkholderia cepacia complex (Bcc). Depletion of the bacterial ETF during infection...
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