Article
Increased tumor-infiltrating CD45RA-CCR7- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Cell death & disease - 17 Aug 2017
Mao Fang-Yuan, Kong Hui, Zhao Yong-Liang, Peng Liu-Sheng, Chen Weisan, Zhang Jin-Yu, Cheng Ping, Wang Ting-Ting, Lv Yi-Pin, Teng Yong-Sheng, Fu Xiao-Long, Liu Yu-Gang, Wu Xiao-Long, Hao Chuan-Jie, You Nan, Luo Ping, Yu Pei-Wu, Zou Quan-Ming, Guo Gang, Zhuang Yuan
Abstract excerpt
Regulatory T cells (Tregs) are major components of tumor-infiltrating immune cells with potent immunosuppressive properties in gastric cancer (GC) microenvironment. However, different subsets of the Tregs and their relevance to GC are unknown. Here, we found that patients with GC showed a significantly higher Tregs infiltration in tumors, and CD45RA-CCR7- Treg subset constituted most tumor-infiltrating Tregs....
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