Article
Methods for the Administration of EDAR Pathway Modulators in Mice.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Schuepbach-Mallepell Sonia, Kowalczyk-Quintas Christine, Dick Angela, Eslami Mahya, Vigolo Michele, Headon Denis J, Cheeseman Michael, Schneider Holm, Schneider Pascal
Abstract excerpt
Genetic deficiency of ectodysplasin A (EDA) causes X-linked hypohidrotic ectodermal dysplasia, a congenital condition characterized by the absence or abnormal formation of sweat glands, teeth, and several skin appendages. Stimulation of the EDA receptor (EDAR) with agonists in the form of recombinant EDA or anti-EDAR antibodies can compensate for the absence of Eda in a mouse model of Eda deficiency, provided...
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