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Article

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.

The Journal of biological chemistry - 29 Sept 2017

Seguin Alexandra, Takahashi-Makise Naoko, Yien Yvette Y, Huston Nicholas C, Whitman Jared C, Musso Gabriel, Wallace Jared A, Bradley Thomas, Bergonia Hector A, Kafina Martin D, Matsumoto Mitsuyo, Igarashi Kazuhiko, Phillips John D, Paw Barry H, Kaplan Jerry, Ward Diane M

Abstract excerpt

ATP-binding cassette subfamily B member 10 (Abcb10) is a mitochondrial ATP-binding cassette (ABC) transporter that complexes with mitoferrin1 and ferrochelatase to enhance heme biosynthesis in developing red blood cells. Reductions in Abcb10 levels have been shown to reduce mitoferrin1 protein levels and iron import into mitochondria, resulting in reduced heme biosynthesis. As an ABC transporter, Abcb10 binds and...

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PMID: 28808058
DOI: 10.1074/jbc.M117.797415
PMCID: PMC5625058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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