Article
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia.
Nature genetics - 1 Nov 1998
Brownlie A, Donovan A, Pratt S J, Paw B H, Oates A C, Brugnara C, Witkowska H E, Sassa S, Zon L I
Abstract excerpt
Many human anaemias are caused by defects in haemoglobin synthesis. The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemoglobin production is perturbed. During embryogenesis, sau mutants have delayed erythroid maturation and abnormal globin gene express...
Topics
- 5-Aminolevulinate Synthetase
- Amino Acid Sequence
- Anemia, Sideroblastic
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Disease Models, Animal
- Hemoglobins
- Humans
- Isoenzymes
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Phenotype
- Sequence Homology, Amino Acid
- Zebrafish