Article
A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.
PLoS genetics - 1 Aug 2017
Cairney Claire J, Godwin Lauren S, Bilsland Alan E, Burns Sharon, Stevenson Katrina H, McGarry Lynn, Revie John, Moore Jon D, Wiggins Ceri M, Collinson Rebecca S, Mudd Clare, Tsonou Elpida, Sadaie Mahito, Bennett Dorothy C, Narita Masashi, Torrance Christopher J, Keith W Nicol
Abstract excerpt
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents and an incomplete understanding of the signalling events underlying this complex...
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