Article
Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy.
Autophagy - 2 Sept 2017
Choutka Courtney, DeVorkin Lindsay, Go Nancy Erro, Hou Ying-Chen Claire, Moradian Annie, Morin Gregg B, Gorski Sharon M
Abstract excerpt
The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-proteasome system and autophagy but how they are molecularly coordinated is not well understood. Here, we demonstrate an essential role for an effector caspase in the activation of compensatory autophagy when proteasomal activity is compromised. Functional loss of Hsp83, the Drosophila ortholog of human HSP90 (heat shock protein...
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