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Article

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance.

Genome biology - 11 Aug 2017

Emad Amin, Cairns Junmei, Kalari Krishna R, Wang Liewei, Sinha Saurabh

Abstract excerpt

BACKGROUND: Identification of genes whose basal mRNA expression predicts the sensitivity of tumor cells to cytotoxic treatments can play an important role in individualized cancer medicine. It enables detailed characterization of the mechanism of action of drugs. Furthermore, screening the expression of these genes in the tumor tissue may suggest the best course of chemotherapy or a combination of drugs to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28800781
DOI: 10.1186/s13059-017-1282-3
PMCID: PMC5554409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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