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Article

HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression

1 Jan 2010

Abstract excerpt

During the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen. However, the regulation of these AR-mediated target genes is not fully understood. We have previously demonstrated a unique role of HOXB13 homeodomain protein as an AR repressor. Expression...

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PMID: 21267402
DOI: 10.5115/acb.2010.43.4.284

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