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Article

Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder.

Biological psychiatry - 15 Dec 2017

Dunlop Boadie W, Binder Elisabeth B, Iosifescu Dan, Mathew Sanjay J, Neylan Thomas C, Pape Julius C, Carrillo-Roa Tania, Green Charles, Kinkead Becky, Grigoriadis Dimitri, Rothbaum Barbara O, Nemeroff Charles B, Mayberg Helen S

Abstract excerpt

BACKGROUND: Medication and psychotherapy treatments for posttraumatic stress disorder (PTSD) provide insufficient benefit for many patients. Substantial preclinical and clinical data indicate abnormalities in the hypothalamic-pituitary-adrenal axis, including signaling by corticotropin-releasing factor, in the pathophysiology of PTSD. METHODS: We conducted a double-blind, placebo-controlled, randomized,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28793974
DOI: 10.1016/j.biopsych.2017.06.024
PMCID: PMC5683912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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