Constraint and Contingency Pervade the Emergence of Novel Phenotypes in Complex Metabolic Systems.

Abstract excerpt

An evolutionary constraint is a bias or limitation in phenotypic variation that a biological system produces. We know examples of such constraints, but we have no systematic understanding about their extent and causes for any one biological system. We here study metabolisms, genomically encoded complex networks of enzyme-catalyzed biochemical reactions, and the constraints they experience in bringing forth novel...

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