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Article

Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.

Stem cells (Dayton, Ohio) - 1 Nov 2017

Teotia Pooja, Van Hook Matthew J, Wichman Christopher S, Allingham R Rand, Hauser Michael A, Ahmad Iqbal

Abstract excerpt

Glaucoma represents a group of multifactorial diseases with a unifying pathology of progressive retinal ganglion cell (RGC) degeneration, causing irreversible vision loss. To test the hypothesis that RGCs are intrinsically vulnerable in glaucoma, we have developed an in vitro model using the SIX6 risk allele carrying glaucoma patient-specific induced pluripotent stem cells (iPSCs) for generating functional RGCs....

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Source

Identifiers

PMID: 28792678
DOI: 10.1002/stem.2675

Genes

SIX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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