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Article

The Tyr113His T/C rs1051740 and 'very slow' phenotype of the EPHX1 gene alters miR-26b-5p and miR-1207-5p expression in pregnancy.

Gene - 30 Oct 2017

Naidoo Pragalathan, Naidoo Rajen N, Ramkaran Prithiksha, Asharam Kareshma, Chuturgoon Anil A

Abstract excerpt

BACKGROUND: Environmental insults and microsomal epoxide hydrolase 1 (EPHX1) single nucleotide polymorphisms (SNPs), Tyr113His T/C rs1051740 and His139Arg A/G rs2234922, aberrantly alters microRNA (miR) expression and are linked to low birthweights (LBW). OBJECTIVES: To investigate the interplay between pollution, EPHX1 SNPs and miRs during pregnancy and associated LBW outcomes. METHODS: South African pregnant...

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Identifiers

PMID: 28789952
DOI: 10.1016/j.gene.2017.07.080

Genes

EPHX1

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