Article
Screening of nucleotide variations in genomic sequences encoding charged protein regions in the human genome.
BMC genomics - 8 Aug 2017
Belmabrouk Sabrine, Kharrat Najla, Abdelhedi Rania, Ben Ayed Amine, Benmarzoug Riadh, Rebai Ahmed
Abstract excerpt
BACKGROUND: Studying genetic variation distribution in proteins containing charged regions, called charge clusters (CCs), is of great interest to unravel their functional role. Charge clusters are 20 to 75 residue segments with high net positive charge, high net negative charge, or high total charge relative to the overall charge composition of the protein. We previously developed a bioinformatics tool (FCCP) to...
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