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Article

Genome-wide analysis of human disease alleles reveals that their locations are correlated in paralogous proteins.

PLoS computational biology - 1 Nov 2008

Yandell Mark, Moore Barry, Salas Fidel, Mungall Chris, MacBride Andrew, White Charles, Reese Martin G

Abstract excerpt

The millions of mutations and polymorphisms that occur in human populations are potential predictors of disease, of our reactions to drugs, of predisposition to microbial infections, and of age-related conditions such as impaired brain and cardiovascular functions. However, predicting the phenotypic consequences and eventual clinical significance of a sequence variant is not an easy task. Computational approaches...

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PMID: 18989397
DOI: 10.1371/journal.pcbi.1000218
PMCID: PMC2565504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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