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Article

Classification of common human diseases derived from shared genetic and environmental determinants.

Nature genetics - 1 Sept 2017

Wang Kanix, Gaitsch Hallie, Poon Hoifung, Cox Nancy J, Rzhetsky Andrey

Abstract excerpt

In this study, we used insurance claims for over one-third of the entire US population to create a subset of 128,989 families (481,657 unique individuals). We then used these data to (i) estimate the heritability and familial environmental patterns of 149 diseases and (ii) infer the genetic and environmental correlations for disease pairs from a set of 29 complex diseases. The majority (52 of 65) of our study's...

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Identifiers

PMID: 28783162
DOI: 10.1038/ng.3931
PMCID: PMC5577363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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