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Article

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.

EBioMedicine - 1 Mar 2025

Murrin Olivia, Mounier Ninon, Voller Bethany, Tata Linus, Gallego-Moll Carlos, Roso-Llorach Albert, Carrasco-Ribelles Lucía A, Fox Chris, Allan Louise M, Woodward Ruby M, Liang Xiaoran, Valderas Jose M, Khalid Sara M, Dudbridge Frank, Lamb Sally E, Mancini Mary, Farmer Leon, Boddy Kate, Bowden Jack, Melzer David, Frayling Timothy M, Masoli Jane A H, Pilling Luke C, Violán Concepción, Delgado João

Abstract excerpt

BACKGROUND: Multimorbidity, the presence of two or more conditions in one person, is common but studies are often limited to observational data and single datasets. We address this gap by integrating large-scale primary-care and genetic data from multiple studies to interrogate multimorbidity patterns and producing digital resources to support future research. METHODS: We defined chronic, common, and heritable...

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Identifiers

PMID: 39919332
DOI: 10.1016/j.ebiom.2025.105584
PMCID: PMC11848100

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