Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.

doi:10.1016/j.ajhg.2017.07.007

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Article

Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.

American journal of human genetics - 3 Aug 2017

Betts Joshua A, Moradi Marjaneh Mahdi, Al-Ejeh Fares, Lim Yi Chieh, Shi Wei, Sivakumaran Haran, Tropée Romain, Patch Ann-Marie, Clark Michael B, Bartonicek Nenad, Wiegmans Adrian P, Hillman Kristine M, Kaufmann Susanne, Bain Amanda L, Gloss Brian S, Crawford Joanna, Kazakoff Stephen, Wani Shivangi, Wen Shu W, Day Bryan, Möller Andreas, Cloonan Nicole, Pearson John, Brown Melissa A, Mercer Timothy R, Waddell Nicola, Khanna Kum Kum, Dray Eloise, Dinger Marcel E, Edwards Stacey L, French Juliet D

Abstract excerpt

Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced...

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Identifiers

PMID: 28777932
DOI: 10.1016/j.ajhg.2017.07.007
PMCID: PMC5544418

Genes

CCND1

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