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Article

Absence of microRNA-21 does not reduce muscular dystrophy in mouse models of LAMA2-CMD.

PloS one - 1 Jan 2017

Moreira Soares Oliveira Bernardo, Durbeej Madeleine, Holmberg Johan

Abstract excerpt

MicroRNAs (miRNAs) are short non-coding RNAs that modulate gene expression post-transcriptionally. Current evidence suggests that miR-21 plays a significant role in the progression of fibrosis in muscle diseases. Laminin-deficient congenital muscular dystrophy (LAMA2-CMD) is a severe form of congenital muscular dystrophy caused by mutations in the gene encoding laminin α2 chain. Mouse models dy3K/dy3K and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28771630
DOI: 10.1371/journal.pone.0181950
PMCID: PMC5542641

Genes

LAMA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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