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Antioxidants Reduce Muscular Dystrophy in the dy<sup>2J</sup>/dy<sup>2J</sup> Mouse Model of Laminin &alpha;2 Chain-deficient Muscular Dystrophy

2020-01-27

Abstract excerpt

Congenital muscular dystrophy with laminin &alpha;2 chain-deficiency (LAMA2-CMD) is a severe neuromuscular disorder without a cure. Using transcriptome and proteome profiling as well as functional assays, we previously demonstrated significant metabolic impairment in skeletal muscle from LAMA2-CMD patients and mouse models. Reactive oxygen species (ROS) increase when oxygen homeostasis is not maintained and here,...

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Literature Corpus work
3a430058-8eac-5466-ac81-1fac6ab9c088
DOI
10.20944/preprints202001.0326.v1
Open publication

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Antioxidants Reduce Muscular Dystrophy in the dy<sup>2J</sup>/dy<sup>2J</sup> Mouse Model of Laminin &alpha;2 Chain-deficient Muscular DystrophyDOI 10.20944/preprints202001.0326.v1
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