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Article

Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies

1 Jan 2011

Abstract excerpt

Laminin-211 is a cell-adhesion molecule that is strongly expressed in the basement membrane of skeletal muscle. By binding to the cell surface receptors dystroglycan and integrin α7β1, laminin-211 is believed to protect the muscle fiber from damage under the constant stress of contractions, and to influence signal transmission events. The importance of laminin-211 in skeletal muscle is evident from...

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PMID: 21798088
DOI: 10.1186/2044-5040-1-9

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