Article
Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release.
International journal of obesity (2005) - 1 Dec 2017
Wentworth J M, Zhang J-G, Bandala-Sanchez E, Naselli G, Liu R, Ritchie M, Smyth G K, O'Brien P E, Harrison L C
Abstract excerpt
BACKGROUND: Inflammatory factors derived from adipose tissue have been implicated in mediating insulin resistance in obesity. We sought to identify these using explanted human adipose tissue exposed to innate and adaptive immune stimuli. METHODS: Subcutaneous and omental adipose tissue from obese, insulin-resistant donors was cultured in the presence of macrophage and T-cell stimuli, and the conditioned medium...
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