Article
Adipocytes modulate the phenotype of human macrophages through secreted lipids.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2013
Klein-Wieringa Inge R, Andersen Stefan N, Kwekkeboom Joanneke C, Giera Martin, de Lange-Brokaar Badelog J E, van Osch Gerjo J V M, Zuurmond Anne-Marie, Stojanovic-Susulic Vedrana, Nelissen Rob G H H, Pijl Hanno, Huizinga Tom W J, Kloppenburg Margreet, Toes René E' M, Ioan-Facsinay Andreea
Abstract excerpt
Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the modulating effects of adipocytes on the phenotype of macrophages in humans...
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