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Article

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.

Molecular carcinogenesis - 1 Dec 2017

Hinrichsen Inga, Weßbecher Isabel M, Huhn Meik, Passmann Sandra, Zeuzem Stefan, Plotz Guido, Biondi Ricardo M, Brieger Angela

Abstract excerpt

MutLα, a heterodimer consisting of MLH1 and PMS2, plays an important role in DNA mismatch repair and has been shown to be additionally involved in several other important cellular mechanisms. Previous work indicated that AKT could modulate PMS2 stability by phosphorylation. Still, the mechanisms of regulation of MutLα remain unclear. The stability of MutLα subunits was investigated by transiently overexpression...

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Source

Identifiers

PMID: 28767177
DOI: 10.1002/mc.22709

Genes

PMS2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.PMID 28767177Read ↗

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