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Article

Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1.

The Journal of biological chemistry - 15 Sept 2017

Oda Takashi, Hirabayashi Hirokazu, Shikauchi Gen, Takamura Ryouma, Hiraga Kiyoshi, Minami Hiroshi, Hashimoto Hiroshi, Yamamoto Masafumi, Wakabayashi Keiji, Shimizu Toshiyuki, Sato Mamoru

Abstract excerpt

ADP-ribosyltransferases transfer the ADP-ribose moiety of βNAD+ to an acceptor molecule, usually a protein that modulates the function of the acceptor. Pierisin-1 is an ADP-ribosyltransferase from the cabbage butterfly Pieris rapae and is composed of N-terminal catalytic and C-terminal ricin B-like domains. Curiously, it ADP-ribosylates the DNA duplex, resulting in apoptosis of various cancer cells, which has...

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PMID: 28765284
DOI: 10.1074/jbc.M117.776641
PMCID: PMC5602402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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