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Article

Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly.

Chemical research in toxicology - 1 Aug 2003

Totsuka Yukari, Kawanishi Masanobu, Nishigaki Rena, Matsukawa Kazuki, Yagi Takashi, Takamura-Enya Takeji, Watanabe Masahiko, Sugimura Takashi, Wakabayashi Keiji

Abstract excerpt

Pierisin-1, an ADP-ribosylating toxin derived from the cabbage butterfly, Pieris rapae, induces apoptosis in various mammalian cell lines. We recently reported that the target for ADP ribosylation by pierisin-1 is the 2'-deoxyguanosine residue in DNA. To examine whether pierisin-1 would induce mutations in mammalian cell genes, we conducted a mutational analysis for the hypoxanthine-guanine...

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PMID: 12924921
DOI: 10.1021/tx034052o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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