Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly.

doi:10.1021/tx600360b

Article

Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly.

Chemical research in toxicology - 1 Apr 2007

Kawanishi Masanobu, Matsukawa Kazuki, Kuraoka Isao, Takamura-Enya Takeji, Totsuka Yukari, Matsumoto Yasuko, Watanabe Masahiko, Zou Yue, Tanaka Kiyoji, Sugimura Takashi, Wakabayashi Keiji, Yagi Takashi

Abstract excerpt

Pierisin-1 is a potent apoptosis-inducing protein found in the pupal extract of the cabbage white butterfly. Pierisin-1 catalyzes the mono(ADP-ribosyl)ation of the 2'-deoxyguanosine residue and produces a bulky adduct, N2-(ADP-ribos-1-yl)-2'-deoxyguanosine (N2-ADPR-dG) in DNA. Here, we examined the involvement of the nucleotide excision repair (NER) system in the removal of N2-ADPR-dG in Escherichia coli (E....

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