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Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight

1 Mar 2019

Abstract excerpt

We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat. Mfn2 mRN was also robustly lower in obese human subjects compared with lean controls. Adipocyte-specific knockdown of Mfn2 in adult mice led to increased food intake, adiposity, and...

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PMID: 30865877
DOI: 10.1016/j.celrep.2019.02.039

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