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Article

Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function

25 Jul 2017

Abstract excerpt

Despite the wide use of mesenchymal stromal cells (MSCs) for paracrine support in clinical trials, their variable and heterogeneous supporting activity pose major challenges. While three-dimensional (3D) MSC cultures are emerging as alternative approaches, key changes in cellular characteristics during 3D-spheroid formation remain unclear. Here, we show that MSCs in 3D spheroids undergo further progression...

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PMID: 28761088
DOI: 10.1038/s41598-017-07049-3

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