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Article

Epigenetic changes of mesenchymal stem cells in three‐dimensional (3D) spheroids

5 Aug 2014

Abstract excerpt

Mesenchymal stem cells (MSCs) hold profound promise in tissue repair/regeneration. However, MSCs undergo remarkable spontaneous differentiation and aging during monolayer culture expansion. In this study, we found that 2-3 days of three-dimensional (3D) spheroid culture of human MSCs (hMSCs) that had been expanded in monolayer for six passages increased their clonogenicity and differentiation potency to neuronal...

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PMID: 25090911
DOI: 10.1111/jcmm.12336

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